tecovirimat will increase the level or outcome of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Tecovirimat is often a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse consequences if coadministered with sensitive substrates of those enzymes.
iloperidone increases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Iloperidone can be a time-dependent CYP3A inhibitor and should cause enhanced plasma levels of medication predominantly removed by CYP3A4.
topiramate will minimize the level or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
prednisone will lessen the extent or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
BRIVIACT will not have to have titration – which implies that you may not should increase your dose more than various weeks. See Getting BRIVIACT for finish info on getting BRIVIACT.
crizotinib raises levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Dose reduction can be essential for coadministered prescription drugs that are predominantly metabolized by CYP3A.
cannabidiol will enhance the amount or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Intently. Take into consideration decreasing the dose of delicate CYP2C19 substrates, as clinically suitable, when coadministered with cannabidiol.
Hematologic Adverse Reactions: Unusual scenarios of pancytopenia, agranulocytosis, and leukopenia have been noted all through postmarketing use in clients handled with APTIOM. Discontinuation of APTIOM should be deemed in patients who build pancytopenia, agranulocytosis, or leukopenia.
eslicarbazepine acetate will raise the amount or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on.
Concomitant use of benzodiazepines and opioids may bring about profound sedation, respiratory despair, coma, and Loss of life
efavirenz will decrease the extent or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
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Monitor Carefully (two)diazepam will improve the degree or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Stay away from concomitant click here utilization of tucatinib with CYP3A substrates, in which small concentration modifications may bring on critical or everyday living-threatening toxicities. If unavoidable, cut down CYP3A substrate dose In line with product labeling.